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Related Experiment Videos

Evidence for gene conversion in genes for cell-adhesion molecules.

J A Gally1, G M Edelman

  • 1Neurosciences Institute of the Neurosciences Research Program, New York, NY.

Proceedings of the National Academy of Sciences of the United States of America
|April 15, 1992
PubMed
Summary

Chicken cell adhesion molecule (K-CAM) and liver cell-adhesion molecule (L-CAM) genes show remarkable similarity in their final exons and introns. This suggests a gene conversion event occurred between these related genes after their evolutionary divergence.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Chicken Ca(2+)-dependent cell adhesion molecule (K-CAM) gene is located upstream of the homologous liver cell-adhesion molecule (L-CAM) gene.
  • K-CAM and L-CAM genes share structural similarities in exon sizes and exon-intron boundary positions.

Purpose of the Study:

  • To compare the genomic sequences of chicken K-CAM and L-CAM genes.
  • To investigate the evolutionary relationship and potential gene conversion events between K-CAM and L-CAM.

Main Methods:

  • Comparative genomic sequence analysis of K-CAM and L-CAM genes.
  • Identification and comparison of exon and intron sequences and sizes.

Main Results:

  • Exon sizes of K-CAM and L-CAM genes are nearly identical.

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  • Intron sequences are largely dissimilar, except for the final two introns.
  • The sequences of the last two exons (15 and 16) and their separating introns show exceptionally high similarity between K-CAM and L-CAM.

    • Conclusions:

    • The high similarity in the terminal exons and introns suggests a gene conversion event.
    • This event likely occurred after the duplication and functional divergence of the K-CAM and L-CAM genes.
    • Gene conversion may play a role in maintaining sequence similarity in specific gene regions despite functional divergence.