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An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze
Published on: July 29, 2025
Strains of rodents and the pharmacology of learning and memory
Martine Ammassari-Teule1, Claudio Castellano
1CNR Institute of Neuroscience, Laboratory of Psychobiology and Psychopharmacology, IRCCS S. Lucia Foundation, Rome, Italy. l.restivo@hsantalucia.it
Abstract:
Mendelian genetic tools have extensively been used to improve the description of the pharmacological mechanisms involved in learning and memory. The first part of this short review describes experiments involving the bidirectional selection of rats or mice for extreme behavioral characteristics or for sensitivity to pharmacological treatments. The second part focuses specifically on in-breeding. In conclusion, the advantages and the limits of a Mendelian pharmacogenetic approach of learning and memory are discussed.