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Updated: Aug 20, 2026

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
Published on: September 1, 2010
[Expression of telomerase activity and c-myc and stimulatory protein 1 in human ameloblastoma]
Ming Zhong1, Zi-juan Li, Jie Wang
1Dept. of Pathology, College of Stomatology, China Medical University, Shenyang 110002, China.
Objective:
To study the oncogene transcriptor c-myc, stimulatory protein 1 (SP1) expression in ameloblastoma (AB) and their relation with telomerase reverse transcripase (hTERT), and to investigate the clinical biological characteristics of AB.
Methods:
The expression was observed in AB by in situ hybridization and SP method.
Results:
The positive rates of c-myc mRNA, hTERT mRNA and SP1 protein were 81.5% (44/54), 94.4% (51/54) and 83.3% (45/54), respectively. Their positive rates increased as AB recurred and transformed malignantly. A strong correlation was found between hTERT and c-myc, hTERT and SP1 (rs = 0.853, P < 0.001; rs = 0.900, P < 0.001).
Conclusion:
Activity of telomerase plays an important role in the tumorigenesis development of AB. Increasing of hTERT expression may be related to c-myc and SP1. The expression of these three parameters has a significant correlation with the clinical biological characteristics of AB.
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