Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The inflammatory reflex--introduction.

J Andersson1

  • 1Department of Medicine, Division of Infectious Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. jan.andersson@medhs.ki.se

Journal of Internal Medicine
|January 20, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strengthening incident learning in radiotherapy practice: insights from the MARLIN study.

Clinical and translational radiation oncology·2026
Same author

Digital health competence among healthcare professionals: A cross-sectional cluster analysis across 19 countries and regions.

International journal of nursing studies·2026
Same author

Healthcare professionals' digital health competence and its core factors; development and psychometric testing of two instruments.

International journal of medical informatics·2023
Same author

Formation and relaxation of K<sup>-2</sup> and K<sup>-2</sup>V double-core-hole states in n-butane.

The Journal of chemical physics·2022
Same author

What drives transmission of severe acute respiratory syndrome coronavirus 2?

Journal of internal medicine·2021
Same author

Neonatal pneumothorax: symptoms, signs and timing of onset in the post-surfactant era.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2021

The nervous system, via the vagus nerve, can reduce sepsis-induced inflammation and mortality. This neuro-immune axis offers new therapeutic targets for sepsis and pain management.

Area of Science:

  • Neuroscience
  • Immunology
  • Pathophysiology

Background:

  • Sepsis is a leading cause of death, characterized by systemic inflammation and organ failure.
  • Current treatments for sepsis have limitations, highlighting the need for novel therapeutic strategies.
  • The neuro-immune axis, the interaction between nervous and immune systems, is a critical area for understanding sepsis.

Purpose of the Study:

  • To explore the role of the neuro-immune axis in sepsis pathogenesis.
  • To review novel aspects of nervous system modulation of the immune response.
  • To discuss potential therapeutic implications of targeting the neuro-immune axis.

Main Methods:

  • Review of existing literature on neuro-immune interactions in sepsis.
  • Analysis of the cholinergic anti-inflammatory pathway.

Related Experiment Videos

  • Examination of the role of the sympathetic nervous system in immune modulation.

    • Main Results:

    • The vagus nerve can modulate tumor necrosis factor-alpha (TNF-alpha) levels, reducing inflammation.
    • Nicotine, an acetylcholine receptor agonist, reduced mortality in established sepsis in studies.
    • Pain associated with inflammation is influenced by immune cells and spinal cord glia, suggesting new pain management targets.

    Conclusions:

    • The neuro-immune axis plays a significant role in sepsis and inflammatory pain.
    • Targeting the cholinergic anti-inflammatory pathway and neuro-immune interactions offers promising therapeutic avenues for sepsis.
    • Understanding the neuro-immune axis may lead to novel treatments for inflammatory conditions and pain.