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Invasive epithelial mesothelioma in a dog
F Reggeti1, B Brisson, K Ruotsalo
1Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada. freggeti@uoguelph.ca
Veterinary Pathology
|January 20, 2005
Summary
This study details an invasive epithelial mesothelioma in a Golden Retriever, highlighting its widespread involvement and malignant cellular features. Immunohistochemistry confirmed neoplastic cells coexpressing vimentin and cytokeratin, aiding diagnosis.
Area of Science:
- Veterinary Pathology
- Oncology
- Canine Neoplasia
Background:
- Mesothelioma is a rare but aggressive tumor arising from mesothelial cells lining body cavities.
- Epithelial mesothelioma presents a diagnostic challenge, particularly in veterinary medicine.
- Accurate characterization is crucial for prognosis and treatment strategies in affected animals.
Observation:
- A case of invasive epithelial mesothelioma in an 11-year-old male Golden Retriever is presented.
- The tumor extensively involved the pericardium, pleura, mediastinum, and peritoneum, with submesothelial tissue invasion.
- Thoracic fluid analysis revealed neoplastic cells with malignant characteristics amidst inflammatory cells and erythrocytes.
Findings:
- Histological examination showed nests of epithelioid cells with high mitotic activity and multinucleation infiltrating tissues.
- Immunohistochemical staining demonstrated strong coexpression of vimentin and cytokeratin in neoplastic cells.
- These markers were essential for differentiating the mesothelioma from other nonmesothelial epithelial tumors.
Implications:
- This case contributes to the understanding of mesothelioma presentation and behavior in canine patients.
- The immunohistochemical profile provides valuable diagnostic criteria for veterinary pathologists.
- Accurate diagnosis of canine mesothelioma impacts clinical management and research into similar human cancers.