Related Experiment Video

Updated: Aug 20, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Botulinum toxin type A in experimental neuropathic pain

L Bach-Rojecky1, M Relja, Z Lacković

  • 1Department of Pharmacology, School of Pharmacy and Biochemistry, University of Zagreb, Croatia.

Journal of Neural Transmission (Vienna, Austria : 1996)
|January 20, 2005
PubMed

Abstract:

A peripheral application of botulinum toxin type A (7 U/kg) has significantly reduced thermal and mechanical hypersensitivity in rats with the partial sciatic nerve transection as a classical model of surgical neuropathy.

More Related Videos

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
08:05

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

Related Experiment Videos

Last Updated: Aug 20, 2026

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
09:39

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
08:05

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

Related Concept Videos

Botulism01:22

Botulism

Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...

Articles linked to this work by shared authors, journal, and citation graph.

A century of phage therapy: from novel discoveries about the past to the challenges of the today.

Die Pharmazie·2021

Botulinum Toxin Type A in Dental Medicine.

Journal of dental research·2019

Role of central versus peripheral opioid system in antinociceptive and anti-inflammatory effect of botulinum toxin type A in trigeminal region.

European journal of pain (London, England)·2017

Botulinum toxin type A in motor nervous system: unexplained observations and new challenges.

Journal of neural transmission (Vienna, Austria : 1996)·2016

Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.

Journal of neural transmission (Vienna, Austria : 1996)·2016

Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats.

Neuroscience letters·2016

Marked intrafamilial phenotypic heterogeneity associated with the CSF1R c.2539G>A pathogenic variant in a Japanese family.

Journal of neural transmission (Vienna, Austria : 1996)·2026

The role of transcranial direct current stimulaton on ataxia: a scoping review.

Journal of neural transmission (Vienna, Austria : 1996)·2026

Diagnostic approach and treatment options for myoclonus.

Journal of neural transmission (Vienna, Austria : 1996)·2026

Uric acid-associated psychopathology in first-episode drug-naïve schizophrenia stratified by depressive symptoms.

Journal of neural transmission (Vienna, Austria : 1996)·2026

Neurofilaments support the differentiation of amyotrophic lateral sclerosis from degenerative cervical myelopathy.

Journal of neural transmission (Vienna, Austria : 1996)·2026

On markers of linguistic impairment in autism and their implementation.

Journal of neural transmission (Vienna, Austria : 1996)·2026

Putative predictive power of baseline cerebrospinal fluid dipeptidyl peptidase-4 on the conversion to secondary progressive multiple sclerosis.

Neurological research·2026

Relationship between Postoperative Neuropathic Pain and Clinical Scores in Patients with Cervical Ossification of the Posterior Longitudinal Ligament.

Spine surgery and related research·2026

Association of peripheral neuropathy severity and cardiac autonomic dysfunction in individuals with neuropathic diabetic foot versus those with diabetic peripheral neuropathy alone.

Diabetes research and clinical practice·2026

Sensor-derived turning measures for differentiating earlier-stage Parkinson's disease and characterizing motor severity.

Parkinsonism & related disorders·2026

Development of a clinical risk score for common peroneal nerve palsy after total knee arthroplasty using a Japanese nationwide database.

International orthopaedics·2026

Molecular mechanism of dynamic regulation of the proNGF/NGF ratio in controlling hair follicle cycle transition in liaoning cashmere goats.

Frontiers in cell and developmental biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us