Related Experiment Video

Updated: Aug 20, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Multiple meningiomas in a patient with Rubinstein-Taybi syndrome. Case report

Marco J T Verstegen1, Pepijn van den Munckhof, Dirk Troost

  • 1Departments of Neurosurgery and Neuropathology, Academic Medical Center, University of Amsterdam, The Netherlands. M.J.Verstegen@amc.uva.nl

Journal of Neurosurgery
|January 22, 2005
PubMed

Insights

This case study details a 37-year-old woman with Rubinstein-Taybi syndrome who presented with multiple meningiomas, including a bifrontal ossifying meningioma. Surgical intervention was performed for the ossifying and a frontoparietal meningioma.

Area of Science:

  • Neuro-oncology
  • Genetics
  • Neurology

Background:

  • Rubinstein-Taybi syndrome (RTS) is a rare genetic disorder associated with an increased risk of developing tumors.
  • Meningiomas are tumors arising from the meninges, the membranes surrounding the brain and spinal cord.

Observation:

  • A 37-year-old female patient with diagnosed Rubinstein-Taybi syndrome presented with multiple intracranial meningiomas.
  • The patient exhibited a bifrontal ossifying meningioma and additional meningiomas within the cranium.

Findings:

  • The case highlights a rare co-occurrence of multiple meningiomas in a patient with Rubinstein-Taybi syndrome.
  • Surgical resection was successfully performed for the bifrontal ossifying meningioma and a right frontoparietal meningioma.

Implications:

  • This case contributes to understanding the potential oncogenic pathways in Rubinstein-Taybi syndrome.
  • Further research may elucidate the specific mechanisms linking RTS to meningioma development.
  • Highlights the importance of vigilant neuro-oncological surveillance in patients with RTS.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...