Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Antibiotics in aerosols].

S Pascal1, P Diot, E Lemarié

  • 1Service de Pneumologie, CHU Bretonneau, Tours.

Revue Des Maladies Respiratoires
|January 1, 1992
PubMed
Summary

Antibiotic aerosols offer improved local drug concentration for bronchopulmonary infections, with higher intrabronchial levels than parenteral routes. While generally well-tolerated, caution is advised for patients with bronchial hyperreactivity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lack of essential medical resources leaves Africa breathless.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same author

Functionalized cationic [4]helicenes with unique tuning of absorption, fluorescence and chiroptical properties up to the far-red range.

Chemical science·2018
Same author

Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics.

International journal of pharmaceutics·2017
Same author

[The pentoxifylline, a corticosteroid sparing in the treatment of sarcoidosis: A case report].

Revue de pneumologie clinique·2017
Same author

Impact on the medical decision-making process of multiplex PCR assay for respiratory pathogens.

Epidemiology and infection·2017
Same author

[The complications of skin expansion in paediatrics: Diagnostic, taking over and prevention].

Annales de chirurgie plastique et esthetique·2016

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Drug Delivery Systems

Context:

  • Bronchopulmonary infections necessitate effective antibiotic delivery.
  • Current treatments often involve systemic administration with potential side effects.
  • Aerosolized antibiotics aim for targeted lung delivery.

Purpose:

  • To evaluate the efficacy and safety of aerosolized antibiotics for bronchopulmonary infections.
  • To compare intrabronchial concentrations with parenteral administration.
  • To explore the potential of aerosol therapy in managing respiratory conditions.

Summary:

  • Aerosolized antibiotics achieve higher local concentrations in airways compared to parenteral routes, though lower than endotracheal instillation.
  • These aerosols are generally well-tolerated but require caution in patients with bronchial hyperreactivity.
  • Current use is limited, primarily in cystic fibrosis (CF) for acute infections and Pseudomonas prevention, and is being explored for bronchiectasis.

Impact:

  • Antibiotic aerosols demonstrate efficacy in acute infectious episodes, comparable to parenteral antibiotics.
  • This delivery method may simplify home-based treatment regimens.
  • Further research is needed to fully elucidate the benefits in conditions like bronchiectasis.

Related Experiment Videos