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Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
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Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro

Published on: June 28, 2024

[Measurement of glutathione]

Hisaichi Fujii1

  • 1Department of Transfusion Medicine and Cell Processing, Tokyo Women's Medical University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 22, 2005
PubMed
Abstract

No abstract available in PubMed .

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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