[Study on the pharmacological mechanism of sodium ferulate for anti-asthmatic effect in guinea pigs]
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Updated: Aug 20, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Yun Sun1, Feng Xu, Hong-Quan Zhang
1Hong-quan Medical College of Yangzhou University, Yangzhou, Jiangsu 225001.
Objective:
To study the anti-asthmatic effect of sodium ferulate (SF) and its mechanism in guinea pig asthmatic model.
Methods:
Guinea pigs were sensitized with ovalbumin as animal asthmatic model and treated with 3 different concentration of SF for 8 days. Levels of endothelin (ET) and nitric oxide (NO) in blood and lung tissue, and eosinophil (EOS) in blood and bronchoalveolar lavage fluid (BLAF) was counted at the end of trial.
Results:
SF could significantly lower the ET content and increase the NO concentration in serum and lung tissue, reduce the number of EOS in blood and BLAF (P < 0.05, P < 0.01). Stronger effect was showed in the high dose group.
Conclusion:
Mechanism of anti-asthmatic action of SF might be to increase NO concentration, lower ET content, alleviate EOS infiltration.
