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Increase in bicarbonate stores with exercise.

T J Barstow1, E M Landaw, C Springer

  • 1Department of Medicine, Harbor-UCLA Medical Center, University of California, School of Medicine, Torrance 90509.

Respiration Physiology
|February 1, 1992
PubMed
Summary
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This study reveals that a common model for bicarbonate exchange dynamics during exercise overestimates bicarbonate stores. A gas exchange method provides a more accurate, smaller estimate of bicarbonate changes during physical activity.

Area of Science:

  • Physiology
  • Exercise Physiology
  • Biochemistry

Background:

  • Previous work established a three-compartment model for human bicarbonate exchange at rest and during exercise.
  • Understanding bicarbonate buffering during exercise is crucial for interpreting metabolic responses.

Purpose of the Study:

  • To evaluate the impact of specific model assumptions on predicting exchangeable bicarbonate changes during exercise.
  • To compare model predictions with direct measurements of carbon dioxide (CO2) retention.

Main Methods:

  • The study tested the effect of applying a rest-based assumption about endogenous CO2 production to exercise conditions within a three-compartment bicarbonate model.
  • CO2 retention was measured using gas exchange data after exercise onset.
  • Changes in tissue bicarbonate were estimated by analyzing oxygen uptake (VO2) and CO2 production (VCO2) kinetics, combined with venous blood gas store changes.

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Main Results:

  • Applying the rest-derived assumption to the exercise condition resulted in a predicted bicarbonate store increase of 700 mmol (over 15 L), deemed unphysiologically large.
  • In contrast, the gas exchange method predicted a much smaller increase in bicarbonate (26 mmol), aligning with existing literature.
  • A significant discrepancy was observed between the model's prediction and the gas exchange measurement.

Conclusions:

  • The assumption regarding the source of endogenous CO2 production in the three-compartment model is incompatible with exercise conditions.
  • The physiological basis of the model's compartments must adapt between rest and exercise.
  • Gas exchange analysis offers a more physiologically relevant estimation of bicarbonate buffering during exercise compared to the tested model assumptions.