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Related Experiment Videos

Receptor editing in peripheral B cell tolerance.

Jeffrey S Rice1, Jeffrey Newman, Chuansheng Wang

  • 1Department of Microbiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Proceedings of the National Academy of Sciences of the United States of America
|January 22, 2005
PubMed
Summary
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Receptor editing, a process in B cells, was observed in mature, antigen-activated cells, not just immature ones. This suggests a role for receptor editing in maintaining peripheral tolerance to self-antigens.

Area of Science:

  • Immunology
  • Molecular Biology
  • Autoimmunity

Background:

  • Receptor editing is a known mechanism for maintaining self-tolerance in immature B cells.
  • Autoreactive B cells undergo secondary immunoglobulin gene rearrangement to prevent autoimmunity.

Purpose of the Study:

  • To investigate if receptor editing occurs in mature, antigen-activated B cells.
  • To explore the role of receptor editing in maintaining peripheral tolerance during an autoreactive response.

Main Methods:

  • Immunization of mice with a peptide mimetope of DNA.
  • Analysis of antigen-specific B cells for phenotype, RAG protein expression, and light chain expression (kappa and lambda).

Main Results:

  • Mice immunized with the DNA mimetope developed peptide- and DNA-reactive antibodies.

Related Experiment Videos

  • Antigen-specific B cells showed a follicular B cell phenotype.
  • Mature B cells in the memory compartment expressed RAG protein and both kappa and lambda light chains, indicating receptor editing.

    • Conclusions:

    • Receptor editing can occur in mature, antigen-activated B cells, challenging previous assumptions.
    • This process in autoreactive B cells may be crucial for maintaining peripheral self-tolerance.