Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uric acid and transplantation.

Marilda Mazzali1

  • 1Division of Nephrology, Universidade Estadual de Campinas, UNICAMP, Campinas-SP, Brazil. mazzma@uol.com.br

Seminars in Nephrology
|January 22, 2005
PubMed
Summary

Posttransplant hyperuricemia, common in organ transplant recipients, may impact graft and patient survival. Managing uric acid levels may improve renal function and graft outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and Effectiveness of Spironolactone to Reduce Proteinuria in Kidney Transplant Recipients During a 5-Year Follow-Up.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2026
Same author

Pregnancy Outcomes Among Women With Kidney Allografts in Brazil: An Integrative Review.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2026
Same author

Promoting Equity in Transplant Research by Addressing the Exclusion of Patients With Glomerular Disease.

Kidney international reports·2025
Same author

Association between carotid sublayers thickness and cardiac alterations in dialysis patients.

Current medical research and opinion·2025
Same author

Genetic Variability in Cisplatin Metabolism in Kidney Injury in Patients With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiotherapy.

Head & neck·2025
Same author

Segmental and Focal Glomerulosclerosis Secondary to MELAS Syndrome and Long-Term Outcomes After Kidney Transplant: Case Report and Literature Review.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation·2025

Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Hyperuricemia is a frequent complication in organ transplant recipients, particularly kidney and heart recipients.
  • It is often linked to chronic cyclosporine immunosuppressive therapy.
  • Risk factors include reduced glomerular filtration rate (GFR), diuretic use, and a prior history of hyperuricemia.

Purpose of the Study:

  • To review the incidence and risk factors of posttransplant hyperuricemia.
  • To discuss the impact of immunosuppressive agents on uric acid metabolism.
  • To suggest alternative treatments for posttransplant hyperuricemia.

Main Methods:

  • Literature review on posttransplant hyperuricemia.
  • Analysis of risk factors and associated conditions.
  • Discussion of treatment strategies and their efficacy.

Main Results:

  • Hyperuricemia is prevalent post-transplant, influenced by GFR, diuretics, and immunosuppressants like cyclosporine.
  • While its direct impact on survival is debated, studies suggest uric acid control may aid renal function recovery.
  • Strategies include adjusting immunosuppression, managing hypertension, nutritional support, and using urate-lowering agents.

Conclusions:

  • Uric acid should be considered a potential risk factor for renal allograft nephropathy and dysfunction.
  • Managing hyperuricemia may improve graft and patient survival in transplant recipients.
  • Further research is needed to clarify the role of uric acid in transplant outcomes.

Related Experiment Videos