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Related Concept Videos

Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Telomeres and Telomerase02:41

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

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Related Experiment Video

Updated: Jul 16, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

Genetics of longevity and aging.

Jan Vijg1, Yousin Suh

  • 1University of Texas Health Science Center, San Antonio, Texas 78245, USA. vijg@uthscsa.edu

Annual Review of Medicine
|January 22, 2005
PubMed
Summary

Genetic factors significantly influence longevity and aging. Research in model organisms and humans highlights metabolism and oxidative stress resistance as key pathways for extending lifespan.

Area of Science:

  • Genetics
  • Aging Research
  • Molecular Biology

Background:

  • Longevity, the capacity for a long life, is fundamentally limited by the aging process.
  • Studies across diverse species, from yeast to humans, reveal a substantial genetic influence on lifespan.
  • Genetic screens in invertebrates have identified pathways involving metabolism and oxidative stress resistance that promote longevity.

Purpose of the Study:

  • To investigate the genetic underpinnings of longevity and aging.
  • To determine if candidate longevity genes identified in model organisms show genetic variation in human populations.
  • To explore the role of cardiovascular disease genes in human longevity.

Main Methods:

  • Comparative genetic analysis across species (yeast, invertebrates, mammals, humans).

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Last Updated: Jul 16, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

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Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

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  • Review of population-based studies on human longevity and cardiovascular disease genes.
  • Proposal for future large-scale case-control studies assessing gene variation and detailed phenotypes.

    • Main Results:

    • Genetic pathways affecting metabolism and oxidative stress resistance are conserved from invertebrates to mammals.
    • Human longevity appears linked to genes associated with cardiovascular disease.
    • Candidate longevity genes from model organisms require validation for lifespan association in human populations.

    Conclusions:

    • Genetic factors play a crucial role in determining lifespan and the aging process.
    • Conserved genetic mechanisms influencing longevity exist across evolutionary diverse species.
    • Future research will utilize large-scale genetic studies to identify specific genes contributing to human aging phenotypes.