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Therapeutic intervention and targets for sepsis
Todd W Rice1, Gordon R Bernard
1Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Center for Lung Research, Nashville, Tennessee 37232-2650, USA. todd.rice@vanderbilt.edu
Annual Review of Medicine
|January 22, 2005
Summary
Sepsis treatment advances include early goal-directed resuscitation and new therapies like activated protein C. Ongoing research explores novel agents to combat severe sepsis, aiming to reduce significant morbidity and mortality.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Pharmacology
Background:
- Sepsis syndrome, a systemic response to infection, leads to severe outcomes.
- Despite advances, severe sepsis remains a major cause of morbidity and mortality.
Purpose of the Study:
- To review recent advances in sepsis treatment.
- To discuss promising novel therapeutic strategies for sepsis.
Main Methods:
- Review of recent research and clinical findings in sepsis management.
- Analysis of novel therapeutic agents targeting sepsis pathophysiology.
Main Results:
- Early goal-directed resuscitation and corticosteroids reduce sepsis mortality.
- Recombinant human activated protein C improves survival in severe sepsis.
Conclusions:
- Understanding sepsis pathophysiology has led to effective treatments.
- Continued investigation into novel therapeutic targets is crucial for improving sepsis outcomes.
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