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Related Experiment Videos

Seizure clustering: risks and outcomes.

Sheryl R Haut1, Shlomo Shinnar, Solomon L Moshé

  • 1Comprehensive Epilepsy Management Center, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York 10467-2490, USA.

Epilepsia
|January 22, 2005
PubMed
Summary
This summary is machine-generated.

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Approximately 29% of epilepsy patients report seizure clusters. Extratemporal epilepsy and a history of head trauma are potential risk factors for clustering, which indicates more intractable epilepsy.

Area of Science:

  • Neurology
  • Epilepsy Research
  • Clinical Neuroscience

Background:

  • Epilepsy is a neurological disorder characterized by recurrent seizures.
  • Seizure clustering, defined as multiple seizures within a 24-hour period, is a common but not fully understood phenomenon.
  • Understanding seizure clustering is crucial for improving patient outcomes and epilepsy management.

Purpose of the Study:

  • To determine the prevalence of self-reported seizure clustering in epilepsy patients.
  • To identify potential risk factors associated with seizure clustering.
  • To explore the outcomes linked to seizure clustering.

Main Methods:

  • A detailed intake questionnaire was used to collect patient data.
  • Subjects reporting three or more seizures in 24 hours were classified as clusterers.

Related Experiment Videos

  • Magnetic resonance imaging (MRI), EEG, International League Against Epilepsy (ILAE) criteria, Beck Anxiety and Depression Inventories, and Quality of Life in Epilepsy testing were utilized.

    • Main Results:

    • Overall, 29% of subjects reported typical seizure clustering.
    • Extratemporal lobe epilepsy (OR, 3.0) and remote symptomatic epilepsy (OR, 2.3), particularly with a history of head trauma (OR, 4.2), were associated with clustering.
    • Clustering correlated with convulsive status epilepticus (SE) (OR, 3.0), seizure-related hospitalization (OR, 5.3), and poorer seizure control.

    Conclusions:

    • Extratemporal epilepsy and head trauma are potential risk factors for seizure clustering.
    • Seizure clustering is associated with convulsive SE and serves as an indicator of more intractable epilepsy.
    • Further research in an ongoing diary study will refine the definition and explore predictors of clustering outcomes.