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Chaperones and slow death--a recipe for tumor immunotherapy

Stuart K Calderwood1

  • 1Molecular and Cellular Radiation Oncology, Department of Radiation Oncology, Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA 02215, USA. scalderw@bidmc.harvard.edu <scalderw@bidmc.harvard.edu>

Trends in Biotechnology
|January 22, 2005
PubMed

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...