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Updated: Aug 20, 2026

Transcriptomic Analysis of C. elegans RNA Sequencing Data Through the Tuxedo Suite on the Galaxy Project
Published on: April 8, 2017
RNAi as a tool to study cell biology: building the genome-phenome bridge
Kristin C Gunsalus1, Fabio Piano
1Center for Comparative Functional Genomics, Department of Biology, New York University, 1009 Silver Center, 100 Washington Sq E, New York, New York 10003, USA.
Abstract:
In the few short years since its discovery, RNA interference (RNAi) has revolutionized the functional analysis of genomes: both technical and conceptual approaches to the investigation of gene function are being transformed as a result of this new technology. Genome-scale RNAi analyses have already been performed in the model organisms Caenorhabditis elegans (in vivo) and Drosophila melanogaster (in cell lines), ushering in a new era of RNAi-based approaches to probing the inner workings of the cell. The transformation of complex phenotypic data into mineable 'digitized' formats is fostering the emergence of a new area of bioinformatics related to the phenome.
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