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Invasive sinusitis due to Pseudallescheria boydii in an immunocompetent host
1Department of Otolaryngology-Head and Neck Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23219-0115.
Southern Medical Journal
|April 1, 1992
Summary
Chronic invasive sinusitis caused by Pseudallescheria boydii is rare in healthy individuals. This case highlights the need for in vitro sensitivity testing to guide effective antifungal treatment.
Area of Science:
- Mycology
- Infectious Diseases
- Otolaryngology
Background:
- Chronic invasive sinusitis is an uncommon infection of the sinuses.
- Pseudallescheria boydii is a fungus that can cause opportunistic infections.
Observation:
- This report details the fourth documented case of sinusitis caused by Pseudallescheria boydii.
- The patient was immunocompetent and had no other significant medical conditions.
Findings:
- Pseudallescheria species typically exhibit sensitivity to ketoconazole.
- Amphotericin B is often not effective at therapeutic levels against Pseudallescheria.
Implications:
- In vitro culture and sensitivity studies are crucial for selecting appropriate antifungal therapy.
- This case underscores the importance of considering rare fungal pathogens in persistent sinusitis, even in immunocompetent hosts.