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Related Experiment Videos

MR quantitation of volume and diffusion changes in the developing brain.

Lijuan Zhang1, Kathleen M Thomas, Matthew C Davidson

  • 1Department of Radiology, Weill Medical College of Cornell University, New York, NY 10021, USA.

AJNR. American Journal of Neuroradiology
|January 22, 2005
PubMed
Summary

Brain diffusion decreases and volume increases during childhood development, with major changes in the first two years. Diffusion-weighted imaging helps quantify these normal brain development changes.

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Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Medical Physics

Background:

  • Understanding normal brain development is crucial for identifying abnormalities.
  • Brain maturation involves significant changes in volume and water diffusion characteristics.
  • Diffusion-weighted imaging (DWI) offers in vivo insights into these developmental processes.

Purpose of the Study:

  • To characterize in vivo volumetric and diffusion changes in the developing brain.
  • To quantify the rate of these changes during pediatric maturation.
  • To assess the utility of a diffusion model for estimating brain volume.

Main Methods:

  • Recruited 30 pediatric volunteers (1 month-17 years).
  • Measured diffusion using DWI with a b value of 1000 s/mm2.

Related Experiment Videos

  • Calculated whole-brain and region-of-interest diffusion parameters, fitting to a triple Gaussian model; measured brain volume using pixel counting and the model.

    • Main Results:

    • Water diffusion decreased significantly in all measured brain regions during maturation, particularly within the first two years.
    • Robust negative correlations were observed between age and average diffusion constant (Dav) values (P <.005).
    • Brain volumes and intracranial volume (ICV) showed rapid increases in the first two years, followed by slower growth through adolescence, with significant age correlations (P <.005).

    Conclusions:

    • Brain diffusion declines while brain volume increases throughout maturation, with the most pronounced changes occurring in early childhood (first two years).
    • The employed brain model effectively estimates brain volume changes during development.
    • DWI provides valuable quantitative data for understanding normal pediatric brain development.