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Published on: July 5, 2021
Secondary supratentorial primitive neuroectodermal tumor following irradiation in a patient with low-grade
Allan Y Chen1, Haidy Lee, Jonathan Hartman
1Department of Radiation Oncology , University of California-Davis Medical Center, Sacramento, CA 95817, USA.
Abstract:
We report a case of a supratentorial primitive neuroectodermal tumor (PNET) that occurred 12 years after cranial irradiation for a grade II astrocytoma. Neuroimaging was unable to distinguish between a recurrence of the original neoplasm and the development of a new, distinct entity. Pathologic review assisted by immunohistochemical staining, however, revealed a high-grade PNET. Although rare, PNET needs to be included in the differential diagnoses for previously irradiated patients, who develop recurrent brain tumors in the presence of uncharacteristic imaging features.
