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The role of models in understanding CD8+ T-cell memory
Rustom Antia1, Vitaly V Ganusov, Rafi Ahmed
1Department of Biology, Emory University, Atlanta, Georgia 30322, USA. rustom.antia@emory.edu
Abstract:
Immunological memory - the ability to 'remember' previously encountered pathogens and respond faster on re-exposure - is a central feature of the immune response of vertebrates. We outline how mathematical models have contributed to our understanding of CD8(+) T-cell memory. Together with experimental data, models have helped to quantitatively describe and to further our understanding of both the generation of memory after infection with a pathogen and the maintenance of this memory throughout the life of an individual.
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