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Published on: March 1, 2018
Tramadol concentrations in blood and in cerebrospinal fluid in a neonate
K Allegaert1, J de Hoon, R Verbesselt
1Department of Paediatrics, University Hospital, Gasthuisberg, Herestraat, Leuven, Belgium. karel.allegaert@uz.kuleuven.ac.be
Abstract:
Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.
