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Related Experiment Videos

New approach to quantifying developmental variation in the dentition using serial microtomographic imaging.

Gal Avishai1, Ralph Müller, Yankel Gabet

  • 1Laboratory of Bio-Anthropology & Ancient-DNA, Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University, Jerusalem, Israel 91120.

Microscopy Research and Technique
|January 22, 2005
PubMed
Summary

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This study used microCT scans to analyze developing human teeth, revealing that cusp coalescence order differs from initiation order. Tooth development allows for significant variation in crown size and form throughout growth.

Area of Science:

  • Developmental biology
  • Human anatomy
  • Paleodontology

Background:

  • Tooth crown morphology reflects dental development and cellular differentiation.
  • The dentin-enamel junction and outer enamel surface are key boundaries for analysis.
  • Imaging technologies allow differentiation of these dental structures.

Purpose of the Study:

  • To quantify enamel and dentin volume in developing human molars using 3D reconstructions.
  • To estimate the order of cusp initiation and coalescence.
  • To investigate variations in tooth development and their contribution to phylogenetic variation.

Main Methods:

  • Serial microCT imaging for accurate 3D reconstructions of developing human second deciduous molars.
  • Quantification of enamel and dentin volume relative to basal crown height.

Related Experiment Videos

  • Analysis of cusp tip and base spatial orientation to infer developmental timing.

    • Main Results:

    • The order of cusp coalescence was found to differ from the order of cusp initiation.
    • Dentin cusp dimensions and enamel apposition rates varied across developmental axes (mesio-distal, bucco-lingual).
    • These variations were independent of initiation order and growth duration, indicating sustained developmental plasticity.

    Conclusions:

    • Developmental variation in tooth crown size and form is maintained throughout the growth process.
    • The developed microCT model offers a novel approach to studying developmental and phylogenetic variations in tooth morphology.