Related Experiment Video
Updated: Feb 19, 2026
An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
Published on: November 15, 2024
Low-grade gliomas treated by fractionated gamma knife surgery
Gabriela Simonová1, Josef Novotny, Roman Liscák
1Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic. gabriela.simonova@homolka.cz
Object:
The authors sought to evaluate local tumor control, complications, and progression-free survival in patients harboring low-grade gliomas who were treated with Leksell gamma knife surgery (GKS).
Methods:
During a 6-year period 70 patients were treated for verified low-grade gliomas (Grade I or II) by GKS. Statistical analysis was based on 68 patients; two patients were lost to follow up. The median patient age was 17 years. The median target volume was 4200 mm.3 The median prescription dose was 25 Gy. The median number of fractions was five. Ninety-five percent of patients were treated in five daily fractions. Partial or complete tumor regression was achieved in 83% of patients with a median time to response of 18 months. There was moderate acute or late toxicity in not more than 5% of patients. In this series the progression-free survival was 92% at 3 years and 88% at 5 years.
Conclusions:
Relatively high local tumor control with minimal complications was achieved.
