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Related Experiment Videos

Gamma knife surgery for hemangioblastomas.

Masao Tago1, Atsuro Terahara, Masahiro Shin

  • 1Department of Radiology, University of Tokyo Hospital, Tokyo, Japan. tago-rad@h.u-tokyo.ac.jp

Journal of Neurosurgery
|January 25, 2005
PubMed
Summary

Stereotactic radiosurgery effectively controls brain hemangioblastomas for up to 10 years, with high tumor control rates. Regular imaging is recommended due to common recurrence outside the treated area.

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Oncology

Background:

  • Hemangioblastomas are rare tumors often associated with von Hippel-Lindau disease.
  • Stereotactic radiosurgery (SRS) is a treatment option for these tumors.

Purpose of the Study:

  • To review a 14-year experience with SRS for hemangioblastomas.
  • To define the role and strategy for radiosurgery in managing hemangioblastomas.

Main Methods:

  • Retrospective study of 38 hemangioblastomas in 13 patients (7 with von Hippel-Lindau disease).
  • Tumors received 18 or 20 Gy SRS.
  • Median clinical follow-up was 36 months; median radiological follow-up was 35 months.

Main Results:

  • 97.4% tumor control rate at 10 years.

Related Experiment Videos

  • 80.8% actuarial survival rate at 10 years.
  • 38.5% of patients developed new or growing lesions outside the irradiated area; larger tumors (>0.5 cm³) showed more peritumoral enhancement.

    • Conclusions:

    • Gamma Knife surgery is safe and effective for hemangioblastoma control up to 10 years.
    • Higher doses and smaller tumors correlate with better outcomes.
    • Regular follow-up and early re-treatment are recommended for new or growing lesions.