Related Experiment Video
Updated: Aug 20, 2026

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
Published on: January 7, 2019
[S2 guideline for infectious endocarditis]
C K Naber1, A Bauhofer, M Block
1Klinik für Kardiologie, Universitätsklinikum Essen.
Abstract:
Microbe-induced (infectious) endocarditis is an endovascular infection, caused mainly by bacteria, of cardiovascular structures. The major predilection site are the native heart valves, but involvement of implanted intracardiac foreign material is increasingly being seen. The mortality rate of infectious endocarditis depends on clinical factors and the causal agent, but also on the time of the establishment of the diagnosis and the initiation of appropriate treatment. In Germany, the current mortality rate ranges up to 18%. Between January 2003 and July 2004, with the aim of improving patient care and thus the outcome of this condition, a guideline commission worked out recommendations for the diagnosis, treatment and management of the disease for the use of general practitioners and hospital physicians, in particular microbiologists, infectiologists, cardiologists and cardiac surgeons. The basis for this guideline was the systematic search through the literature of the European guideline. On the 16th and 28th of June 2004, the entire guideline was formerly approved in a nominal group process.
Insights
Infectious endocarditis, a serious cardiovascular infection, requires timely diagnosis and treatment to reduce its significant mortality rate. This study outlines new guidelines to improve patient care for this condition.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Guidelines
Background:
- Infectious endocarditis is an endovascular infection affecting cardiovascular structures, primarily native heart valves.
- Involvement of implanted intracardiac foreign material is an increasing concern.
- Mortality rates, up to 18% in Germany, are influenced by clinical factors, causative agents, and treatment timeliness.
Purpose of the Study:
- To develop evidence-based recommendations for the diagnosis, treatment, and management of infectious endocarditis.
- To improve patient care and outcomes for infectious endocarditis.
- To provide a guideline for general practitioners and hospital physicians, including specialists like microbiologists, infectiologists, cardiologists, and cardiac surgeons.
Main Methods:
- A guideline commission systematically searched and reviewed existing European guidelines and relevant literature.
- Recommendations were formulated based on the literature review.
- The guideline underwent formal approval via a nominal group process in June 2004.
Main Results:
- A comprehensive guideline for infectious endocarditis diagnosis and management was developed.
- The guideline aims to standardize and improve the care pathway for patients with this condition.
- Recommendations cover diagnosis, treatment, and overall disease management.
Conclusions:
- The developed guideline provides a framework for optimizing the care of patients with infectious endocarditis.
- Implementation of these recommendations is expected to improve patient outcomes.
- The guideline serves as a crucial resource for healthcare professionals involved in managing infectious endocarditis.
Related Concept Videos
Endocarditis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis III: Medical Management
Endocarditis IV: Nursing Management
Myocarditis III: Medical Management
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
