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Updated: Aug 20, 2026

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
[Epigenetic post-transcriptional mechanisms for regulating physiological functions, and their decline during aging]
1Laboratoire de Recherche Ophtalmologique, Université Paris 5, Hôpital Hôtel Dieu, 1, place du Parvis Notre-Dame, 75181 Paris Cedex 04. lrobert5@wanadoo.fr
Abstract:
Sequencing of genomes did not reveal the "secret of life" and left biologists and philosophers unsatisfied. It became clear that post-genetic, epigenetic (taken in a wide sense, post-translational) events play an important role even during development and adult homeostasis. Such mechanisms become predominant during aging, and explain the differential decline of functions (aging in "spare-parts"). Some of these post-translational mechanisms, leading to auto-amplifying vicious circles, will be described.
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