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Updated: Aug 20, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
[Cochlear-vestibular ototoxicity by gentamicin. Report of a case and literature review]
V Pino Rivero1, M Marcos García, T Keituqwa Yáñez
1Facultativo Especialista de Otorrinolaringologia. Hospital Infanta Cristina. vicentepinorivero@terra.com
Abstract:
Gentamicin is an antibiotic member of the aminoglycosides family with well known potential to cause permanent ototoxicity by damaging more likely the cochlea vestibular system. We are reporting the clinical case of a 48 year-old female who was treated with such IV drug because of abdominal surgery. She had no otologic past history, and was complaining of tinnitus, periferical vertigo and progressive bilateral neurosensorial hearing loss, it est, cochlear-vestibular symptoms. After the withdrawol of gentamicin, the vestibular pathologic symptoms but not the hearing loss had improved, docummented by the persistance of the audiometric decay in the acute frequencies. Prevention is the best way to avoid iatrogenic lesions with thesse climps.
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