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Synchronous anal and penile cancers
Wojciech M Wysocki1, Andrzej L Komorowski, Leszek S Kolodziejski
1Department of Surgical Oncology, Maria Skłodowska-Curie Memorial Institute for Oncology, Cancer Center, ul. Garncarska 11, 31-115 Kraków, Poland. z5wysock@cyf-kr.edu.pl
Summary
This report details a rare case of synchronous anal and penile cancers in a 36-year-old man, highlighting shared viral etiologies. Early detection of anogenital cancers is crucial for identifying potential co-existing malignancies.
Area of Science:
- Oncology
- Virology
- Dermatology
Background:
- Anogenital cancers share common etiologies, including viral infections and lifestyle factors.
- Condylomata acuminata are recognized as precancerous lesions in this region.
Observation:
- A 36-year-old male presented with synchronous cancers of the penile foreskin and anus.
- The anal lesion was diagnosed as squamous cell carcinoma, basaloid type.
- The penile lesion was identified as squamous cell carcinoma, keratinizing type.
Findings:
- Both synchronous cancers exhibited an in situ component.
- Histological features (koilocytosis, acanthosis, dyskeratosis) and MIB-1 staining suggested a past viral infection.
- This represents the first reported case of synchronous anal and penile cancers in medical literature.
Implications:
- Shared etiological factors in anogenital malignancies necessitate thorough clinical examination.
- Patients with one anogenital cancer should be screened for other concomitant cancers or precancerous lesions.
- This case underscores the importance of considering multiple primary tumors in the anogenital region.