Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relationship between domain duplication and recombination.

Christine Vogel1, Sarah A Teichmann, Jose Pereira-Leal

  • 1MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 2QH, UK. cvogel@mrc-lmb.cam.ac.uk

Journal of Molecular Biology
|January 25, 2005
PubMed
Summary

Protein domain abundance correlates with versatility, suggesting random recombination. However, specific domain combinations are duplicated, forming "supra-domains" that evolve through selection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elongationless start-stop elements are stress-resilient translation gates that are more repressive than uTranslons.

Nucleic acids research·2026
Same author

Protocadherin-1 deficiency increases baseline and allergen-induced airway hyperresponsiveness in mice.

American journal of respiratory cell and molecular biology·2026
Same author

Heterogeneity and dynamics of DENV-specific CD8 + T cells in dengue infection.

Nature communications·2026
Same author

A Hormone Cell Atlas maps the human endocrine system at cellular resolution.

Science (New York, N.Y.)·2026
Same author

An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity.

Cell press blue·2026
Same author

Decoding Human T Cell Immunity with Artificial Intelligence and Single-Cell Genomics.

Annual review of immunology·2026

Area of Science:

  • Evolutionary biology
  • Proteomics
  • Bioinformatics

Background:

  • Protein domains are fundamental evolutionary units driving protein complexity.
  • Domain duplication and shuffling are key evolutionary mechanisms.
  • Domain abundance and versatility influence proteome complexity.

Purpose of the Study:

  • To analyze the genome-wide relationship between domain abundance and versatility.
  • To investigate the mechanisms of protein evolution driven by domain recombination and duplication.
  • To identify evolutionary units larger than single protein domains.

Main Methods:

  • Comprehensive genome-wide analysis of protein domain relationships.
  • Statistical correlation analysis between domain abundance and versatility.

Related Experiment Videos

  • Simulation of protein repertoire evolution using stochastic recombination and duplication models.

    • Main Results:

    • A strong correlation exists between domain abundance and versatility.
    • Domain recombination appears to be a largely random process.
    • Frequent duplication of specific domain combinations, not all possible combinations, was observed.
    • Simulations incorporating stochastic recombination and combination duplication accurately modeled observed data.
    • Identified "supra-domains" as recurrent, highly duplicated domain combinations.

    Conclusions:

    • Protein evolution involves stochastic domain recombination and selective duplication of domain combinations.
    • Domain combinations are often formed once and then duplicated extensively.
    • "Supra-domains" represent significant evolutionary units beyond single protein domains.