Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Raf phosphorylation: one step forward and two steps back.

Nicolas Dumaz1, Richard Marais

  • 1Signal Transduction Team, Cancer Research UK Centre of Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, United Kingdom.

Molecular Cell
|January 25, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of circulating tumour DNA to prospectively guide a switch from targeted to immune therapy in BRAF mutant advanced melanoma: the randomised phase II CAcTUS trial.

Nature communications·2026
Same author

Expression of Concern: Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma.

Cancer discovery·2026
Same author

Expression of Concern: Inhibiting EGF Receptor or SRC Family Kinase Signaling Overcomes BRAF Inhibitor Resistance in Melanoma.

Cancer discovery·2026
Same author

SOX2 confers tumour permissiveness in a specific skin progenitor population.

Nature communications·2026
Same author

ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma.

Cell reports·2024
Same author

ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma.

Cell reports·2024
Same journal

Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin.

Molecular cell·2026
Same journal

Genome-wide rotational and translational phasing of nucleosomes with human transcription factors.

Molecular cell·2026
Same journal

Spliceosomal proofreading factors safeguard 3' splice-site fidelity and prevent proteotoxicity and inflammation.

Molecular cell·2026
Same journal

Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP.

Molecular cell·2026
Same journal

A bacterial reverse transcriptase: Protein-templated DNA synthesis fuels antiviral immunity.

Molecular cell·2026
Same journal

Tweezing apart ribosome heterogeneity.

Molecular cell·2026
See all related articles

The study reveals the molecular mechanisms behind Raf-1 signaling inactivation, explaining why its activation is transient. This research clarifies the regulation of Raf-1, a key protein in cellular signaling pathways.

Area of Science:

  • Cellular signaling
  • Molecular biology
  • Signal transduction

Background:

  • Raf-1 activation is well-understood, but its inactivation mechanisms remain largely unknown.
  • Understanding Raf-1 inactivation is crucial for comprehending the transient nature of cellular signaling.
  • This study addresses the gap in knowledge regarding Raf-1 signaling termination.

Discussion:

  • The research elucidates the molecular basis for the transient nature of Raf-1 signaling.
  • It identifies key factors and processes that lead to the inactivation of Raf-1.
  • This provides a deeper understanding of signal termination in biological systems.

Key Insights:

  • The study describes the molecular mechanisms underlying Raf-1 signal inactivation.
  • Transient Raf-1 signaling is shown to be a regulated process.

Related Experiment Videos

  • This work sheds light on how cells control the duration of signaling events.

    • Outlook:

    • Further research can explore therapeutic strategies targeting Raf-1 inactivation.
    • This finding may impact the understanding of diseases associated with dysregulated signaling.
    • The study opens new avenues for investigating signal dynamics in various biological contexts.