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Purification of Extracellular Trypanosomes, Including African, from Blood by Anion-Exchangers (Diethylaminoethyl-cellulose Columns)
Published on: April 6, 2019
Trypanocidal activity of extracts and fractions of Bertholletia excelsa
Francinete R Campos1, Ana H Januário, Lisandra V Rosas
1Departamento de Química, Universidade do Amazonas UA, Av. Gal. Otávio Rodrigo Jordão Ramos, 3000 69077-000 Manaus AM, Brazil.
Abstract:
Crude extracts and fractions of Bertholletia excelsa stem barks were tested for trypanocidal activity. Acetone and methanol extracts showed significant in vitro trypanocidal activity against trypomastigote form of Trypanosoma cruzi since in the concentration of 500 microg/ml, the parasites were reduced in 100% and 90.3% respectively, whereas the triterpene betulinic acid pure isolated from hexane extract presented 75.4%.
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