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Nonlinear analysis of RR interval in euthymic bipolar disorder
D Todder1, Y Bersudsky, H Cohen
1Ministry of Health Mental Health Center, Faculty of Health Sciences, Psychiatry Research Unit, Ben Gurion University of the Negev, P.O. Box 4600, Beer-Sheva, Israel. dtoder@netvision.net.il
Background:
The bipolar affective disorder is long been speculated to have an autonomic involvement. Nonlinear analysis of heart rate variability has recently been shown to be a reliable noninvasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function.
Methods:
We studied 32 euthymic bipolar patients and 24 controls. A high-resolution electrocardiogram was obtained during complete rest. Nonlinear analysis (Poincare plot, largest Lyaponuv exponent, minimal embedding dimension, symbolic dynamic) was used.
Results:
There wasn't a statistically significant difference in the nonlinear analysis of the heart rate variability, between the euthymic bipolar patients and controls, in the rest situation.
Conclusion:
The nonlinear analysis of heart rate variability didn't support the notation that there is a disturbance in the autonomic nerves system of bipolar patients in the euthymic state.
