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Related Experiment Videos

Improved outcome for very low birth weight multiple births.

Beatrice Latal Hajnal1, Charlotte Braun-Fahrländer, Kurt von Siebenthal

  • 1Growth and Development Center, University Children's Hospital Zurich, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

Pediatric Neurology
|January 25, 2005
PubMed
Summary

Neurodevelopmental outcomes for very low birth weight multiple births significantly improved between 1983-1994, showing increased cognitive function and disease-free survival. Outcomes for singletons remained unchanged.

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Area of Science:

  • Neonatalogy
  • Developmental Pediatrics
  • Perinatal Epidemiology

Background:

  • Very low birth weight (VLBW) infants, particularly multiples, face significant neurodevelopmental challenges.
  • Previous studies indicate persistent neurodevelopmental deficits in VLBW populations over time.
  • Understanding trends in VLBW multiple births is crucial for assessing the impact of evolving perinatal care.

Purpose of the Study:

  • To analyze temporal trends in neurodevelopmental outcomes for very low birth weight (VLBW) multiple births compared to VLBW singletons.
  • To evaluate changes in cognitive function, cerebral palsy prevalence, and disease-free survival.
  • To determine if improvements in perinatal practices have impacted neurodevelopmental trajectories.

Main Methods:

  • Comparison of two VLBW cohorts: 1983-1985 (n=115) and 1992-1994 (n=144).

Related Experiment Videos

  • Neurodevelopmental assessment at 2 years corrected age using Bayley Scales of Infant Development and neurologic examination.
  • Statistical analysis including analysis of covariance and logistic regression to adjust for neonatal risk factors.

    • Main Results:

    • No significant change in neurodevelopmental outcomes for VLBW singletons between cohorts.
    • Significant improvement in Mental Developmental Index for VLBW multiple births (adjusted mean 81.8 to 96.5, P=0.007).
    • Increased disease-free survival (no cerebral palsy, no developmental delay) in VLBW multiples (7% to 37%, P=0.002); outcomes became similar to singletons in the later cohort.

    Conclusions:

    • Cognitive outcomes for VLBW multiple births have improved, likely due to advancements in perinatal care.
    • Despite improvements, VLBW multiples in the later cohort still exhibited high rates of motor delay and cerebral palsy, similar to singletons.
    • The study highlights the need for continued research and improved interventions for high-risk VLBW infants, especially multiples.