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Updated: Aug 20, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
A new bactericidal lead structure for the protection of materials
Erasmus Vogl1, Rainer Bruns, Oliver Kretschik
1Bayer Chemicals AG, Material Protection Products, BCH-R and D, Geb. I1, 51368 Leverkusen, Germany. erasmus.vogl.ev@bayerchemicals.com
Abstract:
Our search for a new broad spectrum bactericide for preserving materials lead to the discovery of a highly active bicyclic amine (1) and a number of derivatives. The synthesis and biological evaluation as well as a first toxicological assessment of these compounds are described. Compound 1 shows strong bactericidal activity down to levels of below 100 ppm but unfortunately increases the number of mutations in Ames tests.
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