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Updated: Aug 20, 2026
11:19
Inducing a Site Specific Replication Blockage in E. coli Using a Fluorescent Repressor Operator System
Published on: August 21, 2016
Active site directed inhibitors of replication-specific bacterial DNA polymerases
George E Wright1, Neal C Brown, Wei-Chu Xu
1GLSynthesis Inc., One Innovation Drive, Worcester, MA 01605, USA. george.wright@glsynthesis.com
Bioorganic & Medicinal Chemistry Letters
|January 25, 2005
Abstract:
7-Substituted-N(2)-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram(+) bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram(-) bacteria.
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