Related Experiment Videos
Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.) S. Ito
Toshiyuki Takei1, Mitsuru Yoshida, Mayumi Ohnishi-Kameyama
1Fukushima Prefectural Forestry Research Centre, Fukushima, Japan.
Bioscience, Biotechnology, and Biochemistry
|January 25, 2005
Abstract:
Among the lipophilic extracts of seven traditional edible mushrooms, the acetone extract of Sarcodon aspratus markedly inhibited the growth of HL60 human leukemia cells and induced apoptosis after 24 h incubation. The major active component was identified as ergosterol peroxide by NMR and ESI-MS analysis. Ergosterol peroxide completely inhibited growth and induced apoptosis of HL60 cells at a concentration of 25 microM.