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Hyperprolactinemia after low dose of amisulpride
Miloslav Kopecek1, Martin Bares, Jirí Svarc
1Psychiatric Centre Prague, Czech Republic. kopecek@pcp.lf3.cuni.cz
Neuro Endocrinology Letters
|January 25, 2005
Summary
Low doses of amisulpride can cause hyperprolactinemia, a condition of elevated prolactin levels. This effect was observed even when amisulpride was used with antidepressants or benzodiazepines.
Area of Science:
- Endocrinology
- Psychopharmacology
Background:
- Amisulpride is known to cause hyperprolactinemia at antipsychotic doses.
- The effect of low-dose amisulpride on prolactin levels is not well-established.
Purpose of the Study:
- To investigate whether low doses of amisulpride can induce hyperprolactinemia.
- To assess the impact of amisulpride, particularly in combination with other medications, on plasma prolactin levels.
Main Methods:
- Plasma prolactin levels were measured in 10 patients (5 males, 5 females) with depressive symptoms receiving 50 mg of amisulpride daily.
- Patients were treated with amisulpride as monotherapy, augmentation to antidepressants, or anxiolytics.
- Prolactin levels were assessed before and after treatment, with some patients monitored for over a month.
Main Results:
- A significant increase in prolactin levels was observed, from a mean of 16 ng/ml to 113 ng/ml (p=0.027).
- All patients developed hyperprolactinemia (30-200 ng/ml).
- Prolactin levels were significantly higher in females (mean 160 ng/ml) than in males (mean 48 ng/ml; p=0.041).
Conclusions:
- Low-dose amisulpride, even when used as augmentation therapy, is associated with hyperprolactinemia.
- Co-administration with antidepressants and benzodiazepines may intensify prolactin elevation.