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Natural HIV-1 NEF accelerates virus replication in primary human lymphocytes
A de Ronde1, B Klaver, W Keulen
1University of Amsterdam, Academic Medical Centre, Amsterdam.
Virology
|May 1, 1992
Abstract:
HIV-1 NEF genes were isolated directly from peripheral blood lymphocyte DNA of two HIV-1-infected individuals and cloned into an HXB-2-infectious molecular clone. The effect of NEF on virus production in T-cell lines and primary human lymphocytes was studied. Naturally occurring NEF accelerates virus production in primary human lymphocytes, but not in T-cell lines.