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Chronic administration of imipramine decreases freezing time in rats genetically predisposed to catalepsy
A V Kulikov1, M A Tikhonova, V F Chugui
1Laboratory for Neurogenomics of Behavior, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. akulikov@ngs.ru
Bulletin of Experimental Biology and Medicine
|January 25, 2005
Abstract:
The effects of acute and chronic imipramine treatment on the degree of catalepsy were compared in GC rats genetically predisposed to catalepsy. We recorded the time over which the rats remained in a vertical position they were placed. As differentiated from acute treatment, chronic administration of imipramine dose-dependently decreased the time of freezing in GC rats.
