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Updated: Aug 19, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
Familial neurocardiogenic (vasovagal) syncope
Julia L Newton1, Simon Kerr, Jessie Pairman
1Cardiovascular Investigation Unit (Institute for Ageing and Health), School of Clinical Medical Sciences, Newcastle, United Kingdom. julianewton@blueyonder.co.uk
Abstract:
Vasovagal syncope (VSS) is an exaggerated tendency towards the common faint caused by a sudden and profound hypotension with or without bradycardia. The etiology of VVS is unknown though several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Studies however indicate a strong heritable component to the etiology of VVS in over 20% of cases. Here, we report the findings from a family that shows apparently autosomal dominant VVS in at least three generations. Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members.
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