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Turning it up a Notch: cross-talk between TGF beta and Notch signaling

Michael Klüppel1, Jeffrey L Wrana

  • 1Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 25, 2005
PubMed

Insights

Transforming growth factor beta (TGF beta) and Notch signaling pathways interact, influencing embryonic development. This research reveals a direct link, showing Notch is crucial for TGF beta pathway functions in cell fate determination.

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • Transforming growth factor beta (TGF beta) and Notch signaling are vital for embryonic development and cell fate.
  • While both pathways can induce similar cellular responses, their functional interaction was previously undescribed.

Purpose of the Study:

  • To investigate the functional interaction between TGF beta and Notch signaling pathways.
  • To elucidate the role of Notch in mediating TGF beta superfamily signaling responses.

Main Methods:

  • Analysis of gene expression patterns.
  • Assessment of cell differentiation and migration.
  • Investigating the requirement of Notch signal transducers in TGF beta and BMP signaling.

Main Results:

  • Evidence of both synergistic and antagonistic interactions between TGF beta and Notch signaling.
  • Notch signal transducers are required for TGF beta and Bone morphogenetic protein (BMP)-induced gene expression.
  • Notch is essential for BMP-controlled cell differentiation and migration.

Conclusions:

  • A direct functional link between Notch and TGF beta signaling pathways has been uncovered.
  • Notch signaling plays a critical role in mediating biological responses to TGF beta family signaling during embryonic development.

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