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Related Experiment Videos

Solvent/detergent-treated plasma: composition, efficacy, and safety.

Peter Hellstern1

  • 1Institute of Hemostaseology and Transfusion Medicine, Academic City Hospital, Ludwigshafen, Germany. peterhellstern@medicusnet.de

Current Opinion in Hematology
|January 26, 2005
PubMed
Summary

Solvent/detergent-treated plasma (SD-plasma) safety is debated due to varying compositions and potential adverse events like thromboembolism. Further research is needed to optimize SD-plasma and monitor its safety in clinical use.

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Clinical Chemistry

Background:

  • Solvent/detergent-treated plasma (SD-plasma) is a therapeutic plasma product with reported adverse events.
  • Concerns exist regarding SD-plasma efficacy and safety, particularly due to compositional differences among brands.

Purpose of the Study:

  • To review the efficacy and safety of SD-plasma.
  • To investigate reported adverse events associated with SD-plasma, including thromboembolism and hyperfibrinolysis.

Main Methods:

  • Review of retrospective analyses, case reports, prospective trials, observational studies, and post-licensure monitoring.
  • Analysis of literature concerning protein S activity, plasmin inhibitor activity, and hyperfibrinolysis in patients receiving SD-plasma.

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Main Results:

  • While low protein S and plasmin inhibitor levels in SD-plasma have been linked to venous thromboembolism and hyperfibrinolysis, their clinical significance appears overstated.
  • Significant compositional differences exist among SD-plasma brands, potentially influencing hemostatic balance.
  • Specific brands with low citrate and protein S concentrations may contribute to coagulation activation in critical settings like thrombotic thrombocytopenic purpura and liver transplantation.

Conclusions:

  • Future research should focus on optimizing SD-plasma composition.
  • Prospective trials and hemovigilance studies are necessary to accurately determine adverse event rates associated with SD-plasma and other therapeutic plasma products.