The calcium-sensing receptor as a nutrient sensor.

¹Cardiff School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff, CF10 3US, Wales, UK. riccardid@cardiff.ac.uk

|January 26, 2005

Summary

The extracellular-calcium-sensing receptor (CaR) detects external calcium levels, influencing cell fate. This G-protein-coupled receptor also responds to various other molecules, acting as a key metabolic sensor.

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Area of Science:

Biochemistry
Cell Biology
Physiology

Background:

Extracellular calcium concentration ([Ca(2+)](o)) is critical for cell fate.
The extracellular-calcium-sensing receptor (CaR), a G-protein-coupled receptor, mediates cellular responses to [Ca(2+)](o).

Purpose of the Study:

To explore the role of CaR in physiology and disease.
To detail the range of CaR modulators.
To investigate CaR's function as a metabolic sensor.

Main Methods:

Review of existing literature on CaR function.
Analysis of CaR's interaction with various ligands.
Discussion of CaR's role in physiological and pathological contexts.

Main Results:

CaR is activated by calcium and modulated by other cations, polycations, amino acids, polyamines, salinity, and pH.
CaR integrates extracellular calcium signals with local metabolic environmental cues.
CaR plays a role in diverse physiological and pathological scenarios.

Conclusions:

CaR is a versatile receptor with a broad range of modulators.
CaR acts as a crucial metabolic sensor, linking environmental factors to cellular responses.
Understanding CaR function is vital for comprehending cell fate and disease mechanisms.

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Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions: