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Concurrent protein C deficiency and lupus anticoagulants
1Department of Pathology, University of Texas Medical Branch, Galveston 77550.
American Journal of Hematology
|May 1, 1992
Summary
Inherited protein C deficiency can cause deep venous thrombosis and warfarin-induced skin necrosis. This case highlights the severe thrombotic risks when combined with lupus anticoagulants.
Area of Science:
- Hematology
- Genetics
Background:
- Protein C deficiency is an inherited hypercoagulable state.
- It is associated with deep venous thrombosis and warfarin-induced skin necrosis.
Observation:
- A young woman with 45% protein C levels experienced severe deep venous thrombosis and warfarin-induced skin necrosis.
- Lupus anticoagulants were also detected, evidenced by prolonged coagulation times and anticardiolipin antibodies.
Findings:
- The patient developed both venous and arterial thrombosis.
- The co-occurrence of protein C deficiency and lupus anticoagulants likely contributed to severe thrombotic events.
Implications:
- This case underscores the complex thrombotic risks in patients with combined protein C deficiency and lupus anticoagulants.
- Understanding these interactions is crucial for managing hypercoagulable states.