Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Scleroderma in Australian aborigines.

J Zurauskas1, D Beroukas, J G Walker

  • 1Department of Medicine, Allergy and Arthritis, Flinders Medical Centre, Bedford Park, South Australia, Australia.

Internal Medicine Journal
|January 26, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of gastroesophageal reflux disease and its treatment on interstitial lung disease outcomes.

Arthritis research & therapy·2024
Same author

Evidence of chromosomal damage in scleroderma.

Pathology·2021
Same author

Anti-Ro52/TRIM21 is independently associated with pulmonary arterial hypertension and mortality in a cohort of systemic sclerosis patients.

Scandinavian journal of rheumatology·2021
Same author

Is contact between men who have sex with men and non-governmental organizations providing harm reduction associated with improved HIV outcomes?

HIV medicine·2020
Same author

Identification of a unique anti-Ro60 subset with restricted serological and molecular profiles.

Clinical and experimental immunology·2020
Same author

Detectable anti-proteinase-3 antibodies precede clinical manifestations in a case of anti-neutrophil cytoplasmic antibody-associated vasculitis.

Scandinavian journal of rheumatology·2020
Same journal

The paradox of peer review: protecting science or policing thought?

Internal medicine journal·2026
Same journal

Immune-related pancytopenia in pregnancy.

Internal medicine journal·2026
Same journal

Crossover effect: causal machine learning reveals opposing mortality responses to mean arterial pressure targets among phenotypically distinct hypertensive patients with septic shock.

Internal medicine journal·2026
Same journal

Clinicopathological findings, correlations and outcomes in patients with renal disease and living with antiretroviral-treated human immunodeficiency virus infection.

Internal medicine journal·2026
Same journal

Approach to thyroid disorders associated with immune checkpoint inhibitors and tyrosine kinase inhibitors.

Internal medicine journal·2026
Same journal

A scoping review of specialist hypertension clinics.

Internal medicine journal·2026
See all related articles

Scleroderma, or systemic sclerosis, is now documented in Indigenous Australians. While rare, particularly centromere-associated limited scleroderma, its occurrence warrants further investigation in this population.

Area of Science:

  • Rheumatology
  • Immunology
  • Epidemiology

Background:

  • Scleroderma (systemic sclerosis) is a rare autoimmune disease characterized by hardening and tightening of the skin and connective tissues.
  • Previous literature has not documented cases of scleroderma in Australian Aboriginal populations.
  • Understanding the prevalence and specific subtypes of scleroderma in diverse ethnic groups is crucial for accurate diagnosis and management.

Observation:

  • A detailed case of a middle-aged Aboriginal woman with diffuse scleroderma, who succumbed to a renal crisis, is presented.
  • Five additional Aboriginal patients with scleroderma (two diffuse, two limited, one overlap) were identified in South Australia.
  • Analysis of antinuclear antibody (ANA) requests revealed limited occurrence of anticentromere antibodies in Aboriginal individuals.

Related Experiment Videos

Findings:

  • Scleroderma does occur in Indigenous Australians, challenging previous assumptions of its absence.
  • The prevalence of centromere-associated limited scleroderma, common in Caucasians, appears infrequent in Aboriginal individuals.
  • Further research is needed to elucidate the specific immunological profiles and disease manifestations in Indigenous Australians with scleroderma.

Implications:

  • This study highlights the importance of considering scleroderma in the differential diagnosis for Aboriginal patients presenting with relevant symptoms.
  • Findings suggest potential ethnic variations in scleroderma pathogenesis or presentation, particularly regarding antibody specificities.
  • Further epidemiological and immunological studies are essential to confirm the apparent rarity of limited scleroderma in Indigenous Australians and to guide clinical practice.