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Updated: Aug 19, 2026

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections
Published on: August 11, 2012
Pregnancy outcome in recurrent aborters is not influenced by Chlamydia IgA and/or G
Mayumi Sugiura-Ogasawara1, Yasuhiko Ozaki, Tamao Nakanishi
1Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan. og.mym@med.nagoya-cu.ac.jp
Problem:
It is unclear whether chlamydia infection influences the miscarriage rate and immunological factors in patients with recurrent miscarriage.
Method Of Study:
Chlamydia DNA, IgA and IgG to Chlamydia trachomatis, natural killer cell activity, complement 3 (C3), C4, hemolytic complement, antinuclear antibodies, antiphospholipid antibodies, prolactin, activated partial thromboplastin time, prothrombin time and fibrinogen were examined in 504 patients with a history of two or more consecutive first-trimester miscarriages. Subsequent pregnancy outcomes were compared between cases with and without antibodies to C. trachomatis.
Results:
Totals of 10 of 30 and 48 of 201 patients receiving no medication miscarried subsequently with and without chlamydia infection. Chlamydia IgA and/or IgG were associated with a high level of C3 but not other immunological and coagulatory parameters.
Conclusion:
Antibodies to C. trachomatis do not influence subsequent pregnancy outcome in patients with a history of recurrent miscarriage.
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