Related Experiment Video
Updated: Aug 19, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
A phosphatidyl-inositol-3-kinase-dependent anti-inflammatory pathway activated by Salmonella in epithelial cells
Fu-Chen Huang1, Qian Li, Bobby J Cherayil
1Department of Pediatrics, Pediatric Gastroenterology and Nutrition Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Abstract:
Salmonella activates the phosphatidyl-inositol-3-kinase (PI3K)/Akt pathway in epithelial cells, but its role in inflammation has not been previously elucidated. We show here that inhibition of PI3K in T84 intestinal epithelial cells results in augmentation of Salmonella-induced interleukin-8 (IL-8) production at the level of both protein and mRNA. The mechanism of this effect appears to involve altered activation of the extracellular growth factor-regulated kinase (ERK), a molecule that is implicated in the regulation of IL-8 expression. These results identify activation of the PI3K/Akt pathway as an anti-inflammatory signal that may contribute to the establishment of Salmonella in the intestine.
Related Concept Videos
Amebiasis
The JAK-STAT Signaling Pathway
Inflammatory Bowel Disease III: Crohn's Disease
IP3/DAG Signaling Pathway
PI3K/mTOR/AKT Signaling Pathway
Inflammatory Bowel Disease II: Ulcerative Colitis

