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Updated: Aug 12, 2026
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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Synthesis of a peptidocalix[4]arene library and identification of compounds with hydrolytic activity
R Elizabeth Brewster1, Brian G A Dalton, Suzanne Beckham Shuker
1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30329-0400, USA.
Bioorganic Chemistry
|January 26, 2005
Abstract:
A 120 member library of peptidocalix[4]arenes was synthesized and screened for catalysis of the hydrolysis of p-nitrophenyl acetate. His-Ser-His-calix[4]arene was found to catalyze this reaction with v(0)=3.24 x 10(-8)M/s, an increase of 1520% above background and 30% above the tripeptide (His-Ser-His) alone.
